MODIFIED PICTET-SPENGLER REACTION AND PRODUCTS PREPARED THEREFROM

A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.

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Bibliographische Detailangaben
Hauptverfasser:	PAWLAK JOSEPH MATTHEW, MARTINELLI MICHAEL JOHN, ORME MARK W, CHELIUS ERIK CHRISTOPHER, DOECKE CHRISTOPHER WILLIAM
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.