1H-IMIDAZOLE DERIVATIVES AS POTENT CANNABINOID-CB1 RECEPTOR AGONISTS, PARTIAL AGONISTS OR ANTAGONISTS, METHODS OF THEIR PREPARATION (VARIANTS), INTERMEDIATES, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARATION THEREOF

1H-IMIDAZOLE DERIVATIVES AS POTENT CANNABINOID-CB1 RECEPTOR AGONISTS, PARTIAL AGONISTS OR ANTAGONISTS, METHODS OF THEIR PREPARATION (VARIANTS), INTERMEDIATES, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARATION THEREOF

The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and 10 pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agoni...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KRUSE CORNELIS G, HERREMANS ARNOLDUS H.J
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and 10 pharmaceutical compositions containing one or more of these compounds as an active component. These 1H-imidazole derivatives are potent cannabinoid-CB1 receptor agonists, partial agonists or antagonists, useful for the treatment of psychiatric and neurological disorders, as well as and other diseases involving cannabinoid neurotransmission. The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification. , (I)