7(6)- DIFLUOROMETHOXY -3-METHYL-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE

7(6)- DIFLUOROMETHOXY -3-METHYL-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE

Difluoromethoxy -3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide of the general formula (I), where Ia: R1 = H, R2 = OCHF2; Ib: R1 = OCHF2, R2 = H. Such compounds which are fluorine-containing analogs of diazoxide act on heart wok indices, vessels tonus and hemodynamic indices similarly to diazoxide,...

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Hauptverfasser: YAHUPOLSKYI LEV MUSIIOVYCH, MALIETINA IRYNA ISAAKIVNA, MOIBENKO OLEKSII OLEKSIIOVYCH
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Difluoromethoxy -3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide of the general formula (I), where Ia: R1 = H, R2 = OCHF2; Ib: R1 = OCHF2, R2 = H. Such compounds which are fluorine-containing analogs of diazoxide act on heart wok indices, vessels tonus and hemodynamic indices similarly to diazoxide, but have a series of advantages, in particular reveal large vasodilatatory properties and do not reveal arrhythmogenic effect.