6-METHYL-2,4-DIHYDROXYPYRIMIDINE -5-SULFONAMIDE DERIVATIVES AND A METHOD FOR THE PREPARATION THEREOF

6-METHYL-2,4-DIHYDROXYPYRIMIDINE -5-SULFONAMIDE DERIVATIVES AND A METHOD FOR THE PREPARATION THEREOF

Proposed is a method for the preparation of aryl sulfonamides of the general formula of RSO2NHArR'(I) based on 6-methyl-2,4-dihydroxypyrimidine-5-sulfochloride and primary amines of aromatic series, where R is residue of 6-methyl-2,4- dihydroxypyrimidine with sulphonamide group in the position...

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Hauptverfasser: POTAPENKO EDUARD VOLODYMYROVYCH, ISAK OLEKSANDR DEMIANOVYCH, POHORIELOVA IRYNA PETRIVNA
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator POTAPENKO EDUARD VOLODYMYROVYCH
ISAK OLEKSANDR DEMIANOVYCH
POHORIELOVA IRYNA PETRIVNA
description Proposed is a method for the preparation of aryl sulfonamides of the general formula of RSO2NHArR'(I) based on 6-methyl-2,4-dihydroxypyrimidine-5-sulfochloride and primary amines of aromatic series, where R is residue of 6-methyl-2,4- dihydroxypyrimidine with sulphonamide group in the position of 5;Ar is the residue of benzene; R' = alkyl (C1-C6), alkoxy, carboxy, alkoxy carbonyl, halogen, nitro, trifluoromethyl, dialkylamino, sulphonamido and other functional groups. Sulphonamides can find application as biologically active sulphonamide agents against staphylococci, colon bacillus, dysentery and etc. Sulfochlorides interact with amines in aqueous solution or organic solvent.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 6-METHYL-2,4-DIHYDROXYPYRIMIDINE -5-SULFONAMIDE DERIVATIVES AND A METHOD FOR THE PREPARATION THEREOF
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