ACYLATED INDANYL AMINES, USE THEREOF, PHARMACEUTICAL BASED THEREON AND A METHOD FOR SYNTHESIS THEREOF

The present invention relates to acylated indanyl amines according to the general formula (I) where R1 R4 have the meanings given in the description, A is CH2 CHOH or CH-(C1-C3-alkyl), B is CH2 or CH-(C1-C3-alkyl), and R5 is an aryl or heteroaryl group, possibly substituted by the substituents listed in the description. These compounds are useful in the upregulation of endothelial nitric oxide synthase (eNOS), and may therefore be useful for the manufacture of medicaments for the treatment of cardiovascular diseases stable or unstable angina pecions, coronary heart disease, Prinymetal angina, aclue coronary syndrome, heart failure, myocardial interaction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, restenosis endothel damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, reno vascular hypertension, chronic glomerulonephritis, erectile disfunction ventricular arrhythmia, diabetes ordiabetes complications, nephropathy or retinopathy, angiopenesis asthma bronchiale chronic renal failure, cirrhosis of the liver, osteoporosis, restricted memory performance, a restricted ability to learn, or for the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives