METHOD FOR INHIBITING MICROORGANISMS BY BLOCKING SIGNATURE SEQUENCES OF THEIR RIBOSOMAL RNA BY COMPLEMENTARY (ANTISENSE) OLIGODEOXYRIBONUCLEOTIDES

METHOD FOR INHIBITING MICROORGANISMS BY BLOCKING SIGNATURE SEQUENCES OF THEIR RIBOSOMAL RNA BY COMPLEMENTARY (ANTISENSE) OLIGODEOXYRIBONUCLEOTIDES

The method for inhibiting the microorganisms by blocking the signature sequences of their ribosomal RNA (rRNA) by the complementary (antisense) oligodeoxyribonucleotides provides for the use of synthesized complementary oligodeoxyribonucleotides protected from the nucleases. Such oligodeoxyribonucle...

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Hauptverfasser: YEHOROV OLEH VOLODYMYROVYCH, SKRYPAL IVAN HAVRYLOVYCH, FEDORIAK DMYTRO MYKHAILOVYCH, DUBEI IHOR YAROSLAVOVYCH
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The method for inhibiting the microorganisms by blocking the signature sequences of their ribosomal RNA (rRNA) by the complementary (antisense) oligodeoxyribonucleotides provides for the use of synthesized complementary oligodeoxyribonucleotides protected from the nucleases. Such oligodeoxyribonucleotides are capable for penetrating the bacterial cells with the aid of the active transport. Inside the cells, complementary oligodeoxyribonucleotides target corresponding rRNA due to Watson-Crick interactions inhibiting thus the self-assembly of ribosomal subunits and the protein synthesis eventually killing the bacteria.