CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

A class of polycyclic compounds of general formula (I), of general formula (II), or of general formula (Io), wherein Base1. Base2, Y, Yа, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a , R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type...

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Hauptverfasser: Chang, Wonsuk, Otte, Ryan, D, Jewell, James, P, Zhao, Kake, Walsh, Shawn, P, Liang, Rui, Lu, Min, Trotter, Benjamin Wesley, Altman, Michael, D, Lim, Jongwon, Siu, Tony, Truong, Quang, T, Liu, Hong, Henderson, Timothy, J, Childers, Matthew Lloyd, Andresen, Brian, Northrup, Alan, B, Cumming, Jared, N, Haidle, Andrew Marc
Format: Patent
Sprache:eng ; ukr
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Zusammenfassung:A class of polycyclic compounds of general formula (I), of general formula (II), or of general formula (Io), wherein Base1. Base2, Y, Yа, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a , R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.