DERIVATIVES OF 7-[(2-AMINOETHYL)BENZYLAMINO]-2-OXO-2H-CHROMENE-3-CARBOXIMIDAMIDES AND SALTS THEREOF

The invention relates to organic chemistry, in particular to novel derivatives of 7-[(2-aminoethyl)benzylamino]-2-oxo-2H-chromene-3-carboximidamides of general formula I, including optical and geometric isomers and pharmaceutically acceptable salts thereof. EMBED ISISServer wherein R1 and R2 independently is hydrogen, (C1-C6)alkyl, cyclo(C1-C6)alkyl, (C1-C6)alkenyl, (C1-C6)alkinyl, aryl, aryl(C1-C6)alkyl, hetaryl, hetaryl(C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxy, cyclo(C1-C6)alkoxy, aryl(C1-C6)alkoxy, hetaryl(C1-C6)alkoxy, halo(C1-C6)alkoxy, amino, (C1-C6)alkylamino, cyclo(C1-C6)alkylamino, di(C1-C6)alkylamino, dicyclo(C1-C6)alkylamino, amino(C1-C6)alkyl, aminocyclo(C1-C6)alkyl, mono(C1-C6)alkylamino(C1-C6)alkyl, monocyclo(C1-C6)alkylamino(C1-C6)alkyl, di(C1-C6)alkylamino(C1-C6)alkyl, dicyclo(C1-C6)alkylamino(C1-C6)alkyl, (C1-C6)alkylcarbonyl, cyclo(C1-C6)alkylcarbonyl, arylcarbonyl, hetarylcarbonyl, aryl(C1-C6)alkylcarbonyl, hetaryl(C1-C6)alkylcarbonyl, (C1-C6)alkylcarbonylamino, cyclo(C1-C6)alkylcarbonylamino, arylcarbonylamino, hetarylcarbonylamino, aryl(C1-C6)alkylcarbonylamino, hetaryl(C1-C6)alkylcarbonylamino, (C1-C6)alkoxycarbonyl, cyclo(C1-C6)alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, aryl(C1-C6)alkoxycarbonyl, hetaryl(C1-C6)alkoxycarbonyl, hydroxycarbonyl, aminocarbonyl, (C1-C6)alkylaminocarbonyl, cyclo(C1-C6)alkylaminocarbonyl, di(C1-C6)alkylaminocarbonyl, dicyclo(C1-C6)alkylaminocarbonyl, (C1-C6)alkylsulphonyl, cyclo(C1-C6)alkylsulphonyl, aryl(C1-C6)alkylsulphonyl, hetaryl(C1-C6)alkylsulphonyl, arylsulphonyl, hetarylsulphonyl, hetaryl(C1-C6)alkylsulphonyl, (C1-C6)alkylaminosulphonyl, cyclo(C1-C6)alkylaminosulphonyl, di(C1-C6)alkylaminosulphonyl, dicyclo(C1-C6)alkylaminosulphonyl, arylaminosulphonyl, hetarylaminosulphonyl, aminosulphonyl, (C1-C6)alkylsulphonylamino, cyclo(C1-C6)alkylsulphonylamino, di(C1-C6)alkylsulphonylamino, dicyclo(C1-C6)alkylsulphonylamino, arylsulphonylamino, hetarylsulphonylamino, aryl(C1-C6)alkylsulphonylamino, hetaryl(C1-C6)alkylsulphonylamino, halogen, OH, CN, NO2; n means a number of independent different or identical R1 substituents and equals to 1, 2 or 3; m means a number of independent different or identical R2 substituents and equals to 1, 2, 3, 4, 5; R3 and R4 independently mean (C1-C6)alkyl, cyclo(C1-C6)alkyl, (C1-C6)alkenyl, (C1-C6)alkinyl, aryl, aryl(C1-C6)alkyl, hetaryl, hetaryl(C1-C6)alkyl, halo(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C