TWI848171B

The present invention pertains to diquafosol or a salt thereof, and an aqueous ophthalmic composition containing polyvinylpyrrolidone. The present invention further pertains to an aqueous ophthalmic composition for preventing or treating dry eye, the composition containing a 3% (w/v) concentration of sodium diquafosol, polyvinylpyrrolidone having a K value of 90, and silver nitrate, and the composition being characterized by being used so as to be ocularly administered at a dosage of 1 or 2 drops 2 to 4 times daily. The present invention also pertains to an aqueous ophthalmic composition for preventing or treating dry eye, the composition containing a 3% (w/v) concentration of sodium diquafosol, polyvinylpyrrolidone, and silver nitrate, the composition being characterized by being used so as to be ocularly administered at a dosage of one or two drops, two to four times daily, wherein the viscosity is 3 to 30 mPa·s at 25°C.