Modified guide rnas

This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, AMY MADISON RHODEN, STRAPPS, WALTER, MORRISSEY, DAVID V
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.