Arginine deiminase with reduced cross-reactivity toward adi-peg 20 antibodies for cancer treatment

Arginine deiminase with reduced cross-reactivity toward adi-peg 20 antibodies for cancer treatment

The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the AD...

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Bibliographische Detailangaben
Hauptverfasser: SISSON, WES, CHEN, LIANG, ALMASSY, ROBERT, SHIA, WEI-JONG, LEE, YANG, SHOWALTER, RICHARD, THOMSON, JAMES A
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.