Novel process for the preparation of carboprost tromethamine

The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are se...

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Bibliographische Detailangaben
Hauptverfasser:	KARDOS, ZSUZSANNA, HORTOBAGYI, IREN, JUHASZ, IMRE, VARADI, CSABA, NAGYNE BORKO, AGNES, BUZDER LANTOS, PETER, LASZLOFI, ISTVAN, FONAGY, LASZLO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.