Azithromycin multiparticulate dosage forms by liquid-based processes

Liquid-based processes are disclosed for forming azithromycin multiparticulates having minimal amounts of azithromycin esters. A liquid-based process for the formation of multiparticulates comprising the steps: (a) forming a mixture comprising azithromycin, a pharmaceutically acceptable carrier, and...

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Bibliographische Detailangaben
Hauptverfasser:	CREW, MARSHALL DAVID, FRIESEN, DWAYNE THOMAS, MCCRAY, SCOTT BALDWIN, APPEL, LEAH ELIZABETH, LYON, DAVID KEITH
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MAKING GRANULES OR PREFORMS MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PREPARATION OR PRETREATMENT OF THE MATERIAL TO BESHAPED PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIALCONTAINING PLASTICS TRANSPORTING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:	Liquid-based processes are disclosed for forming azithromycin multiparticulates having minimal amounts of azithromycin esters. A liquid-based process for the formation of multiparticulates comprising the steps: (a) forming a mixture comprising azithromycin, a pharmaceutically acceptable carrier, and at least one liquid having a boiling point of less than about 150 C; (b) forming particles from said mixture of step (a) by a method selected from (i) atomization of said mixture, and (ii) coating seed cores with said mixture; and (c) removing a substantial portion of said liquid from said particles of step (b) to form said multiparticulates wherein the following expression is satisfied: [A]