Substituted 3-cyano quinolines

This invention provides compounds having the formula, wherein: X is cyclohexyl, pyridinyl or phenyl ring, wherein pyridinyl group could be substituted by Br, or phenyl ring could be optionally mono-, di- or tri-substituted, and the substituents are selected from the group consisting of halogen, C6-1 alkyl, C2-6 alkynyl, azido, C1-6 hydroxyalkyl, halomethyl, C1-4 alkoxymethyl, C1-4 alkoxy, C1-4 alkylthio, hydroxy, trifluoromethyl, cyano, C1-4 carboalkyl, phenoxy, amino, C1-4 alkylamino, C1-4 dialkylamino, acetamido, butynamido; n is 0-1; Y is -NH-, -O-, -S-, or -NR-; R is C1-4 alkyl; R1 is hydrogen, C1-4 alkoxy; R2 is hydrogen, halogen, C1-4 alkoxymethyl, C1-6 alkoxy, hydroxy, nitro, ammo, R5-CONH(CH2)p-, R8-C=C-CONH(CH2)p-, wherein R5 is C1-4 alkyl, and the alkyl could be optionally substituted by one halogen; R6 is hydrogen; R7 is chloro or bromo; R8 is hydrogen, methyl, C1-3 alkylaminoalkyl, C1-3 N,N-dialkylaminoalkyl, morpholine-N-C1-3 alkyl, N-C1-3-alkyl-piperazino-N-C1-3 alkyl, C1-3 alkoxyalkyl, C1-3 hydroxyalkyl, chloro or bromo; Z is C1-3 alkyloxy or morpholino; p is 0; q is 1 to 3; R3 is hydrogen, hydroxy, C1-6 alkoxy (alkyl could be optionally substituted by one halogen), C1-4 alkoxyalkoxy, phenyl-C1-4 alkyloxy; R4 is hydrogen, C1-4 alkyl (alkyl could be optionally substituted by one halogen), C1-4 alkyoxy, di-C1-4 alkylaminoalkyl, or R2 and R3 together could form a diradial of -O-(CH2)2-O-; or a pharmaceutically acceptable salt thereof with the proviso that when Y is -NH-, R1, R2, R3, and R4 are hydrogen, and n is 0, X is not 2-methylphenyl, which are inhibitors of protein tyrosine kinase.