Pharmaceutical composition for combination of piperidinoalkanol-decongestant

The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising: (a) a first discrete zone made with Formulation (A) which comprises, a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18% to about 39% by weight of formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of: (i) carnauba wax in an amount of about 59% to about 81% by weight of formulation (A); and (ii) a suitable antiadherent in an amount of about 0.25% to about 2.00% by weight of Formulation (A); wherein said first carrier base material provides a sustained release of the sympathomimetic drug; and (b) a second discrete zone made with formulation (B) which comprises a therapeutically effective antihistaminic amount of a piperidinoalkanol, or a pharmaceutically acceptable salt thereof, in an amount of about 15% to about 30% by weight of formulation (B) and a second carrier base material, the second carrier base comprising a mixture of; (i) a cellulose diluent in an amount of about 27% to about 73% by weight of formulation (B); (ii) pregelatinized starch in an amount of about 15% to about 30% by weight of formulation (B); (iii) a suitable disintegrant in an amount of about 0.25% to about 6.00% by weight of formulation (B); and (iv) a suitable lubricant in an amount of about 0.25% to about 2.00% by weight of formulation (B); wherein said second carrier base material provides an immediate release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof.