Biotin derivatives

Biotin compounds of the formula I in which Q is absent, -NH-(CH2)-n-CO or -NH- (CH2)n-NH- and R1 is X-Arg-Gly-Asp-Y, A-Cys(R2)-B-U or cyclo-(Arg-Gly-Asp-Z), where Z is bonded in the side chain to Q or, if Q is absent, to biotin, and A, B, U, X, Y, Z and n have the meanings stated in claim 1, and the...

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Bibliographische Detailangaben
Hauptverfasser:	DIEFENBACH, BEATE DR, JONCZYK, ALFRED DR, GOODMAN, SIMON DR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	Biotin compounds of the formula I in which Q is absent, -NH-(CH2)-n-CO or -NH- (CH2)n-NH- and R1 is X-Arg-Gly-Asp-Y, A-Cys(R2)-B-U or cyclo-(Arg-Gly-Asp-Z), where Z is bonded in the side chain to Q or, if Q is absent, to biotin, and A, B, U, X, Y, Z and n have the meanings stated in claim 1, and their salts can be used as integrin inhibitors, in particular for the prophylaxis and treatment of disorders of the circulation, for thrombosis, myocardial infarct, coronary heart diseases, arteriosclerosis, angiogenic disorders and in tumour therapy.