Substituted oximes as neurokinin antagonists

Substituted oximes as neurokinin antagonists

Compounds within the genus represented by the structural formula I or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R1 is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -C...

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Bibliographische Detailangaben
Hauptverfasser: REICHARD, GREGORY A, ALAIMO, CHERYL A, CARRUTHERS, NICHOLAS I., SHIH, NENG-YANG, TING, PAULINE C
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds within the genus represented by the structural formula I or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R1 is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, R4 is methyl or ethyl; and Z is substituted piperidinyl.