New polymorphic form of doxazosin mesylate (form II)

A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterised in its X-ray spectrum by the following reflex positions of high and medium intensity: 10.68 DEG, 23.45 DEG, 14.45 DEG, 23.82 DEG, 17.37 DEG, 24.30 DEG. Owing to its...

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Hauptverfasser: MORSDORF, JOHANN PETER, GRAFE, INGOMAR
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GRAFE, INGOMAR
description A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterised in its X-ray spectrum by the following reflex positions of high and medium intensity: 10.68 DEG, 23.45 DEG, 14.45 DEG, 23.82 DEG, 17.37 DEG, 24.30 DEG. Owing to its crystalline properties, the new form of doxazosin mesylate according to the invention has surprising advantages both with regard to its synthesis and for pharmaceutical processing into solid dosage forms. A process for preparing the new form of doxazosin mesylate and medicaments containing the new form of doxazosin mesylate are also described.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title New polymorphic form of doxazosin mesylate (form II)
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