Process for providing a stable form of a fine-grained inhalation pharmaceutical composition and fine-grained inhalation pharmaceutical composition

The present invention relates to a process for providing a stable crystallinic form to a fine-grained substance or a substance mixture, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of such a substance or a substance mixture, by (a) in case of a substance mixture, preparing a homogenous mixture of the substances; (b) micronizing, direct precipitating or diminishing by any conventional method the substance or substance mixture into a particle size required for inhalation, the particle size being less than 10 mu m; (c) optionally preparing a homogenous mixture of the desired substances when each substance has been introduced from stage (b) as separate fine-grained particles; (d) conditioning said substance or substance mixture by treatment with a water containing vapor phase in a controlled fashion; and (e) drying.