Substituted 4-phenylthiazole derivatives, process for their preparation and pharmaceutical compositions containing them

The invention concerns compounds of formula I, in which R1 represents hydrogen, C1-C5 alkyl, C3-C8 cycloalkyl, aralkyl whose alkyl part has from 1 to 5 carbon atoms, an alkoxycarbonylalkyl group or an (alkoxycarbonylaryl)-alkyl group in which the alkoxy and alkyl parts have from 1 to 3 carbon atoms; a carboxyalkyl group or a (carboxyaryl)alkyl group in which the alkyl part has from 1 to 3 carbon atoms; A represents either (i) a methylene group optionally mono- or disubstituted by a C1-C5 alkyl group, by an alkoxycarbonyl group whose alkoxy part has from 1 to 5 carbon atoms, by an alkoxycarbonylalkyl group in which the alkoxy and alkyl parts have from 1 to 5 carbon atoms, by a carboxyalkyl group whose alkyl part has from 1 to 5 carbon atoms, by a group chosen from phenyl and benzyl which are unsubstituted or substituted on the aromatic ring by C1-C5 alkyl, C1-C5 alkoxy, hydroxyl, halogen or trifluoromethyl, by a pyridyl group, or (ii) an ethylene group; R represents hydrogen, a C1-C5 alkyl group, an aryl group or an aralkyl group whose alkyl part has from 1 to 5 carbon atoms, the said aryl and aralkyl groups being unsubstituted or substituted on the aromatic ring by hydroxyl, C1-C3 alkoxy, C1-C3 alkanoyloxy, halogen, trifluoromethyl or C1-C5 alkyl; Y represents hydrogen; a -COOR2 group in which R2 represents a C1-C5 alkyl group; an aryl group or an aralkyl group whose alkyl part has from 1 to 5 carbon atoms, it being possible for the said aryl and aralkyl groups to be optionally substituted on the aromatic ring by C1-C5 alkyl; or a -COR3 group in which R3 represents C1-C5 alkyl; or one of their salts.