Methods for the preparation of biphenyl isoxazole sulfonamides

Methods for the preparation of biphenyl isoxazole sulfonamides

A method for the preparation of a compound of the following formula Ia: and enantiomers and diastereomers, and salts thereof, wherein: R1 and R2 are each directly bonded to a ring carbon and are each hydrogen; X is O; Y is N; R3 and R4 are independently hydrogen or C1-6 alkyl; R11, R12, R13 and R14...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: POLNIASZEK, RICHARD P, GADAMASETTI, KUMAR G., DEPUE, JEFFERY S, WANG, XUEBAO, PANDIT, CHENNAGIRI R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A method for the preparation of a compound of the following formula Ia: and enantiomers and diastereomers, and salts thereof, wherein: R1 and R2 are each directly bonded to a ring carbon and are each hydrogen; X is O; Y is N; R3 and R4 are independently hydrogen or C1-6 alkyl; R11, R12, R13 and R14 are each independently hydrogen; J is O; K is N; L is C; P is 0; (b) deprotecting the nitrogen of said formula Iva compound or salt thereof to form said compound of the formula Ia or salt thereof.