Process for producing guanidine derivatives, intermediates therefor and their production

A process for producing a compound (VI) or a salt thereof, (VI) (where, R1 is C1-4 alkyl, R2 is H, Q is a pyridyl or thiazolyl, which is arbitrarily substituted by halogen, X is nitro, and n is 0 or 1), the process comprising: (A) reacting a compound of the following formula or a salt thereof, (II)...

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Hauptverfasser: ISHITSUKA MASASHI, SAIJYO HIDEO, TAKANOBU MASAHITO, KAMIYA YASUO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:A process for producing a compound (VI) or a salt thereof, (VI) (where, R1 is C1-4 alkyl, R2 is H, Q is a pyridyl or thiazolyl, which is arbitrarily substituted by halogen, X is nitro, and n is 0 or 1), the process comprising: (A) reacting a compound of the following formula or a salt thereof, (II) (where, the definition of the symbol is the same as the above), with a compound of the following formula or a salt thereof, (V) (where, the definitions of the symbols are the same the above), or (B) reacting a compound of the formula (II) or a salt thereof with a compound of the following formula, (III) (where, A is o-phenylene, and Y1 and Y2 are identical or different and represent a detaching group), to obtain a compound of the following formula, (IV) (where, the definition of the symbol is the same as the above), and reacting the compound of the formula (IV) with a compound of the formula (V) or a salt thereof.