Novel ATP-sensitive potassium channel potentiators, their preparation and use

The invention relates to compounds of general formula (I) or a pharmaceutically acceptable salt, solvate and/or hydrate thereof, methods for their preparation, the use of said compounds for use as a medicament, and their use in the treatment and/or prevention of a disease or disorder. In an embodime...

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Hauptverfasser: VAN DER SANDE, CLAUDINE, VIVET, BERTRAND, MEVELLEC, LAURENCE ANNE, WIGERINCK, PIET
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creator VAN DER SANDE, CLAUDINE
VIVET, BERTRAND
MEVELLEC, LAURENCE ANNE
WIGERINCK, PIET
description The invention relates to compounds of general formula (I) or a pharmaceutically acceptable salt, solvate and/or hydrate thereof, methods for their preparation, the use of said compounds for use as a medicament, and their use in the treatment and/or prevention of a disease or disorder. In an embodiment, the disease or disorder is hyperinsulinism, in particular congenital hyperinsulinism. The invention also relates to a pharmaceutical composition comprising a compound of general formulas (I) and a pharmaceutically acceptable carrier and its use as a medicament, in particular its use in the treatment of a disease or disorder, such as hyperinsulinism or congenital hyperinsulinism.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Novel ATP-sensitive potassium channel potentiators, their preparation and use
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