Novel ATP-sensitive potassium channel potentiators, their preparation and use

The invention relates to compounds of general formula (I) or a pharmaceutically acceptable salt, solvate and/or hydrate thereof, methods for their preparation, the use of said compounds for use as a medicament, and their use in the treatment and/or prevention of a disease or disorder. In an embodiment, the disease or disorder is hyperinsulinism, in particular congenital hyperinsulinism. The invention also relates to a pharmaceutical composition comprising a compound of general formulas (I) and a pharmaceutically acceptable carrier and its use as a medicament, in particular its use in the treatment of a disease or disorder, such as hyperinsulinism or congenital hyperinsulinism.