Compositions and methods for delivery of therapeutic agents to bone

Macromolecule compositions and related methods that effect targeted delivery of therapeutic agents to effector targets in bone tissue while minimizing or avoiding undesirable delivery to other cells, tissues or organs are provided. Compositions and methods related to macromolecules, such as an ANDbo...

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Bibliographische Detailangaben
Hauptverfasser:	KOHAR, VIVEK, ROTHSCHILDS, ADRIENNE MARIE, KAHVEJIAN, AVAK, AFEYAN, NOUBAR BOGHOS, ECHELARD, YANN PAUL GUY REGIS, AFEYAN, RAFFI, NICOD, CHARLOTTE MARIE, AZHAR, NABIL, CARLSON, SCOTT MOORE, BLOM, DANIEL, MARSHALL, STEPHEN, LUENGO, FRANCISCO JAVIER CULLERE, KINLOCH, ANDREW JAMES, PLUGIS, NICHOLAS MCCARTNEY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Macromolecule compositions and related methods that effect targeted delivery of therapeutic agents to effector targets in bone tissue while minimizing or avoiding undesirable delivery to other cells, tissues or organs are provided. Compositions and methods related to macromolecules, such as an ANDbodyTM, that include an effector target binding domain specific for an effector target, and an address binding domain specific for bone tissue are described.