Engineered retrons and methods of use

Disclosed are engineered retrons and methods of use such as to modify the genome of a host (e.g., mammalian) cell by delivering the engineered retron or the encoded ncRNA in vitro or in vivoto the host (e.g., mammalian) cell.

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Bibliographische Detailangaben
Hauptverfasser:	LADHA, ALIM, SCULLY, STEPHEN, YI, ZHONG-XIA, QUINLAN, DEVIN SCOTT, BEITANS, ABRIL FLEITAS, MESTRE, MARIO RODRIGUEZ, LAYER, JACOB, SHCHERBAKOVA, INNA, PRESNYAK, VLADIMIR, KIEFFER-KWON, KYONG-RIM, JAYARAMAN, MUTHUSAMY, LY, SOCHEATA, GOODMAN, BRIAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are engineered retrons and methods of use such as to modify the genome of a host (e.g., mammalian) cell by delivering the engineered retron or the encoded ncRNA in vitro or in vivoto the host (e.g., mammalian) cell.