Novel ACC inhibitors
A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bi...
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creator | GERSTENBERGER, BRIAN STEPHEN DOW, ROBERT LEE INGLE, GAJENDRA CHOI, CHULHO PARIKH, MIHIR DINESHKUMAR BOOTSMA, ANDREA NICOLE O'BRIEN, JESSICA GLORIA KATHERINE EDMONDS, DAVID JAMES SCHMITT, DANIEL COPLEY BAGLEY, SCOTT WILLIAM GARCIA-IRIZARRY, CARMEN NOEMI RESCOURIO, GWENAELLA CHRISTINE |
description | A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele |
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INGLE, GAJENDRA ; CHOI, CHULHO ; PARIKH, MIHIR DINESHKUMAR ; BOOTSMA, ANDREA NICOLE ; O'BRIEN, JESSICA GLORIA KATHERINE ; EDMONDS, DAVID JAMES ; SCHMITT, DANIEL COPLEY ; BAGLEY, SCOTT WILLIAM ; GARCIA-IRIZARRY, CARMEN NOEMI ; RESCOURIO, GWENAELLA CHRISTINE</creatorcontrib><description>A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240416&DB=EPODOC&CC=TW&NR=202415668A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240416&DB=EPODOC&CC=TW&NR=202415668A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GERSTENBERGER, BRIAN STEPHEN</creatorcontrib><creatorcontrib>DOW, ROBERT LEE</creatorcontrib><creatorcontrib>INGLE, GAJENDRA</creatorcontrib><creatorcontrib>CHOI, CHULHO</creatorcontrib><creatorcontrib>PARIKH, MIHIR DINESHKUMAR</creatorcontrib><creatorcontrib>BOOTSMA, ANDREA NICOLE</creatorcontrib><creatorcontrib>O'BRIEN, JESSICA GLORIA KATHERINE</creatorcontrib><creatorcontrib>EDMONDS, DAVID JAMES</creatorcontrib><creatorcontrib>SCHMITT, DANIEL COPLEY</creatorcontrib><creatorcontrib>BAGLEY, SCOTT WILLIAM</creatorcontrib><creatorcontrib>GARCIA-IRIZARRY, CARMEN NOEMI</creatorcontrib><creatorcontrib>RESCOURIO, GWENAELLA CHRISTINE</creatorcontrib><title>Novel ACC inhibitors</title><description>A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBDxyy9LzVFwdHZWyMzLyEzKLMkvKuZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfEh4UYGRiaGpmZmFo7GxKgBAB7UIHk</recordid><startdate>20240416</startdate><enddate>20240416</enddate><creator>GERSTENBERGER, BRIAN STEPHEN</creator><creator>DOW, ROBERT LEE</creator><creator>INGLE, GAJENDRA</creator><creator>CHOI, CHULHO</creator><creator>PARIKH, MIHIR DINESHKUMAR</creator><creator>BOOTSMA, ANDREA NICOLE</creator><creator>O'BRIEN, JESSICA GLORIA KATHERINE</creator><creator>EDMONDS, DAVID JAMES</creator><creator>SCHMITT, DANIEL COPLEY</creator><creator>BAGLEY, SCOTT WILLIAM</creator><creator>GARCIA-IRIZARRY, CARMEN NOEMI</creator><creator>RESCOURIO, GWENAELLA CHRISTINE</creator><scope>EVB</scope></search><sort><creationdate>20240416</creationdate><title>Novel ACC inhibitors</title><author>GERSTENBERGER, BRIAN STEPHEN ; DOW, ROBERT LEE ; INGLE, GAJENDRA ; CHOI, CHULHO ; PARIKH, MIHIR DINESHKUMAR ; BOOTSMA, ANDREA NICOLE ; O'BRIEN, JESSICA GLORIA KATHERINE ; EDMONDS, DAVID JAMES ; SCHMITT, DANIEL COPLEY ; BAGLEY, SCOTT WILLIAM ; GARCIA-IRIZARRY, CARMEN NOEMI ; RESCOURIO, GWENAELLA CHRISTINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_TW202415668A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GERSTENBERGER, BRIAN STEPHEN</creatorcontrib><creatorcontrib>DOW, ROBERT LEE</creatorcontrib><creatorcontrib>INGLE, GAJENDRA</creatorcontrib><creatorcontrib>CHOI, CHULHO</creatorcontrib><creatorcontrib>PARIKH, MIHIR DINESHKUMAR</creatorcontrib><creatorcontrib>BOOTSMA, ANDREA NICOLE</creatorcontrib><creatorcontrib>O'BRIEN, JESSICA GLORIA KATHERINE</creatorcontrib><creatorcontrib>EDMONDS, DAVID JAMES</creatorcontrib><creatorcontrib>SCHMITT, DANIEL COPLEY</creatorcontrib><creatorcontrib>BAGLEY, SCOTT WILLIAM</creatorcontrib><creatorcontrib>GARCIA-IRIZARRY, CARMEN NOEMI</creatorcontrib><creatorcontrib>RESCOURIO, GWENAELLA CHRISTINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GERSTENBERGER, BRIAN STEPHEN</au><au>DOW, ROBERT LEE</au><au>INGLE, GAJENDRA</au><au>CHOI, CHULHO</au><au>PARIKH, MIHIR DINESHKUMAR</au><au>BOOTSMA, ANDREA NICOLE</au><au>O'BRIEN, JESSICA GLORIA KATHERINE</au><au>EDMONDS, DAVID JAMES</au><au>SCHMITT, DANIEL COPLEY</au><au>BAGLEY, SCOTT WILLIAM</au><au>GARCIA-IRIZARRY, CARMEN NOEMI</au><au>RESCOURIO, GWENAELLA CHRISTINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel ACC inhibitors</title><date>2024-04-16</date><risdate>2024</risdate><abstract>A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | Novel ACC inhibitors |
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