Novel ACC inhibitors

A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bi...

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Hauptverfasser: GERSTENBERGER, BRIAN STEPHEN, DOW, ROBERT LEE, INGLE, GAJENDRA, CHOI, CHULHO, PARIKH, MIHIR DINESHKUMAR, BOOTSMA, ANDREA NICOLE, O'BRIEN, JESSICA GLORIA KATHERINE, EDMONDS, DAVID JAMES, SCHMITT, DANIEL COPLEY, BAGLEY, SCOTT WILLIAM, GARCIA-IRIZARRY, CARMEN NOEMI, RESCOURIO, GWENAELLA CHRISTINE
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creator GERSTENBERGER, BRIAN STEPHEN
DOW, ROBERT LEE
INGLE, GAJENDRA
CHOI, CHULHO
PARIKH, MIHIR DINESHKUMAR
BOOTSMA, ANDREA NICOLE
O'BRIEN, JESSICA GLORIA KATHERINE
EDMONDS, DAVID JAMES
SCHMITT, DANIEL COPLEY
BAGLEY, SCOTT WILLIAM
GARCIA-IRIZARRY, CARMEN NOEMI
RESCOURIO, GWENAELLA CHRISTINE
description A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele
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INGLE, GAJENDRA ; CHOI, CHULHO ; PARIKH, MIHIR DINESHKUMAR ; BOOTSMA, ANDREA NICOLE ; O'BRIEN, JESSICA GLORIA KATHERINE ; EDMONDS, DAVID JAMES ; SCHMITT, DANIEL COPLEY ; BAGLEY, SCOTT WILLIAM ; GARCIA-IRIZARRY, CARMEN NOEMI ; RESCOURIO, GWENAELLA CHRISTINE</creatorcontrib><description>A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; 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R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Novel ACC inhibitors
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