Novel ACC inhibitors

A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GERSTENBERGER, BRIAN STEPHEN, DOW, ROBERT LEE, INGLE, GAJENDRA, CHOI, CHULHO, PARIKH, MIHIR DINESHKUMAR, BOOTSMA, ANDREA NICOLE, O'BRIEN, JESSICA GLORIA KATHERINE, EDMONDS, DAVID JAMES, SCHMITT, DANIEL COPLEY, BAGLEY, SCOTT WILLIAM, GARCIA-IRIZARRY, CARMEN NOEMI, RESCOURIO, GWENAELLA CHRISTINE
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and -(CH2)m-W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl,, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, -SO2-R', -CONR'R", NR'COR", -NR'CONR'R", -NR'CO2R", -(CH2)n-SO2-R', -NHSO2-R', -NR"SO2-R', -SO2NR'R", NR'R" or SR' where R' and R'' are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms sele