Polycyclic KIF18A inhibitor, and pharmaceutical composition, preparation method and use thereof

Polycyclic KIF18A inhibitor, and pharmaceutical composition, preparation method and use thereof

The present disclosure provides a compound shown in general formula (I), pharmaceutical composition, preparation method and use thereof. The compound has a good KIF18A inhibitory effect, and can regulate the KIF18A protein alone or by forming binding complexes with microtubules, for the treatment of...

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Hauptverfasser: WANG, SI-QIN, YANG, FANG-LONG, JIN, LEI, LU, BIAO, ZHANG, CHEN
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Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator WANG, SI-QIN
YANG, FANG-LONG
JIN, LEI
LU, BIAO
ZHANG, CHEN
description The present disclosure provides a compound shown in general formula (I), pharmaceutical composition, preparation method and use thereof. The compound has a good KIF18A inhibitory effect, and can regulate the KIF18A protein alone or by forming binding complexes with microtubules, for the treatment of KIF18A mediated diseases and/or conditions, such as tumor diseases, and the preparation of drugs for such diseases or conditions.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Polycyclic KIF18A inhibitor, and pharmaceutical composition, preparation method and use thereof
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