Polycyclic KIF18A inhibitor, and pharmaceutical composition, preparation method and use thereof

Polycyclic KIF18A inhibitor, and pharmaceutical composition, preparation method and use thereof

The present disclosure provides a compound shown in general formula (I), pharmaceutical composition, preparation method and use thereof. The compound has a good KIF18A inhibitory effect, and can regulate the KIF18A protein alone or by forming binding complexes with microtubules, for the treatment of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG, SI-QIN, YANG, FANG-LONG, JIN, LEI, LU, BIAO, ZHANG, CHEN
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides a compound shown in general formula (I), pharmaceutical composition, preparation method and use thereof. The compound has a good KIF18A inhibitory effect, and can regulate the KIF18A protein alone or by forming binding complexes with microtubules, for the treatment of KIF18A mediated diseases and/or conditions, such as tumor diseases, and the preparation of drugs for such diseases or conditions.