Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with FC-engineering
The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human N...
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| creator | CHIRON, MARIELLE MASIERO, ALESSANDRO BENINGA, JOCHEN LANGE, CHRISTIAN GAUTHIER, LAURENT VIRONE-ODDOS, ANGELA FOCKEN, INGO GOURDIN, NICOLAS TILLMANN, BODO TANG, ALEXANDRE RAO, SAMBASIVA ZHOU, YAN-FENG SEVIGNY, LEILA |
| description | The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-[gamma] receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM). |
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The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).</description><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240401&DB=EPODOC&CC=TW&NR=202413419A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240401&DB=EPODOC&CC=TW&NR=202413419A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHIRON, MARIELLE</creatorcontrib><creatorcontrib>MASIERO, ALESSANDRO</creatorcontrib><creatorcontrib>BENINGA, JOCHEN</creatorcontrib><creatorcontrib>LANGE, CHRISTIAN</creatorcontrib><creatorcontrib>GAUTHIER, LAURENT</creatorcontrib><creatorcontrib>VIRONE-ODDOS, ANGELA</creatorcontrib><creatorcontrib>FOCKEN, INGO</creatorcontrib><creatorcontrib>GOURDIN, NICOLAS</creatorcontrib><creatorcontrib>TILLMANN, BODO</creatorcontrib><creatorcontrib>TANG, ALEXANDRE</creatorcontrib><creatorcontrib>RAO, SAMBASIVA</creatorcontrib><creatorcontrib>ZHOU, YAN-FENG</creatorcontrib><creatorcontrib>SEVIGNY, LEILA</creatorcontrib><title>Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with FC-engineering</title><description>The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-[gamma] receptor. 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The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with FC-engineering |
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