Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with FC-engineering

Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with FC-engineering

The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human N...

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Bibliographische Detailangaben
Hauptverfasser: CHIRON, MARIELLE, MASIERO, ALESSANDRO, BENINGA, JOCHEN, LANGE, CHRISTIAN, GAUTHIER, LAURENT, VIRONE-ODDOS, ANGELA, FOCKEN, INGO, GOURDIN, NICOLAS, TILLMANN, BODO, TANG, ALEXANDRE, RAO, SAMBASIVA, ZHOU, YAN-FENG, SEVIGNY, LEILA
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-[gamma] receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).