Nucleic acids for inhibiting expression of AGT in a cell

The invention relates to double-stranded nucleic acid molecules that interfere with or inhibit angiotensinogen (AGT) gene expression. It further relates to therapeutic uses of such inhibition such as for the treatment of AGT-mediated diseases, disorders or syndromes, such as hypertension, pregnancy-...

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Bibliographische Detailangaben
Hauptverfasser:	MORRISON, ELIOT, JOHANNSSEN, TIMO, DAMES, SIBYLLE, CZAJKOWSKI, MACIEJ
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to double-stranded nucleic acid molecules that interfere with or inhibit angiotensinogen (AGT) gene expression. It further relates to therapeutic uses of such inhibition such as for the treatment of AGT-mediated diseases, disorders or syndromes, such as hypertension, pregnancy-associated hypertension, borderline hypertension, diabetic hypertension, resistant hypertension, primary hypertension, secondary hypertension, chronic heart failure, stroke, non-alcoholic steatohepatitis (NASH), and/or non-alcoholic fatty liver disease (NAFLD).