Anti-meEGFR antibody, antigen-binding fragment thereof, and uses thereof

The invention relates to an anti-meEGFR antibody or an antigen-binding fragment thereof, a detection kit, a method of detecting meEGFR-positive cancer, a pharmaceutical composition for treating cancer, a meEGFR specific chimeric antigen receptor, a nucleic acid encoding the meEGFR specific chimeric...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SHEN, YIUN, WANG, SHAOUN, YAMAGUCHI, HIROHITO, LIN, YOU-ZHE, HUNG, MIENIE, HSU, JUNG-MAO, LI, HONG-WEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to an anti-meEGFR antibody or an antigen-binding fragment thereof, a detection kit, a method of detecting meEGFR-positive cancer, a pharmaceutical composition for treating cancer, a meEGFR specific chimeric antigen receptor, a nucleic acid encoding the meEGFR specific chimeric antigen receptor, a meEGFR specific chimeric antigen receptor expressing cell, an innate cell engager, and an antibody conjugate. The anti-meEGFR antibody or the antigen-binding fragment thereof specifically binds to a methylated epidermal growth factor receptor (meEGFR), and the meEGFR is asymmetric-dimethylated at R198 and R200 residues. Therefore, the anti-meEGFR antibody or the antigen-binding fragment thereof can be used as a detection kit for detecting meEGFR-positive cancer and applied to the treatment of meEGFR-positive cancer.