Pharmaceutical compositions comprising WRN helicase inhibitors

Disclosed are compounds of Formula (I):, or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

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Bibliographische Detailangaben
Hauptverfasser:	KIKUCHI, SHOTA, ROGNESS, DON, OWYANG, ZACH, GREEN, JASON, WEINSTEIN, DAVID, BURGESS, LARRY, HORNING, BENJAMIN, LAM, BETTY, LAMB, KELSEY, MALMSTROM, ROBERT
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula (I):, or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.