EPHA2-targeting antibodies and their applications in cancer treatment

The present disclosure relates to anti- EphA2 antibody and cancer detection (or diagnosis) and treatment using the anti- EphA2 antibody. The present invention creates anti- EphA2 antibodies, particularly, a single-chain antibody fragments (scFv) and humanized antibody, which have ability in binding...

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Bibliographische Detailangaben
Hauptverfasser:	CHANG, FU-LING, YEN, YUN, LEE, YUING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present disclosure relates to anti- EphA2 antibody and cancer detection (or diagnosis) and treatment using the anti- EphA2 antibody. The present invention creates anti- EphA2 antibodies, particularly, a single-chain antibody fragments (scFv) and humanized antibody, which have ability in binding to anti- EphA2 and in inhibiting angiogenesis, migration and cancer cell growth.