Gamma delta T-cell-targeted modified IL-2 polypeptides and uses thereof

Provided herein are polypeptides comprising at least one VHH domain that binds [gamma][delta] TCR and a modified IL-2. Uses of the polypeptides are also provided.

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Bibliographische Detailangaben
Hauptverfasser:	TIMMER, JOHN C, BECKLUND, BRYAN R, ECKLES, ANDREW M, ECKELMAN, BRENDAN P, ROBINSON, KAITLYN N, JONES, KYLE S
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are polypeptides comprising at least one VHH domain that binds [gamma][delta] TCR and a modified IL-2. Uses of the polypeptides are also provided.