Spiroheterocyclic derivatives having serotonin receptor binding activity

Provided are compounds having a serotonin 5-HT2A receptor antagonism and/or inverse agonism or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a hydrogen atom or the l...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YASUI, RINA, UENO, TATSUHIKO
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Provided are compounds having a serotonin 5-HT2A receptor antagonism and/or inverse agonism or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a hydrogen atom or the like; A1 is each independently CR2R2'; A2 is each independently CR3CR3'; R2 is each independently a hydrogen atom or the like; R2' is each independently a hydrogen atom or the like; R3 is each independently a hydrogen atom or the like; R3' is each independently a hydrogen atom or the like; m and n are each independently 1 or the like; the ring B is a ring represented by the Formula: wherein: R4 is a group represented by the Formula: wherein: A3 is each independently CR13R13'; A4 is each independently CR14CR14'; R13 is each independently a hydrogen atom or the like; R13' is each independently a hydrogen atom or the like; R14 is each independently a hydrogen atom or the like; R14' is each independently a hydrogen atom