Spiroheterocyclic derivatives having serotonin receptor binding activity
Provided are compounds having a serotonin 5-HT2A receptor antagonism and/or inverse agonism or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a hydrogen atom or the l...
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Zusammenfassung: | Provided are compounds having a serotonin 5-HT2A receptor antagonism and/or inverse agonism or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a hydrogen atom or the like; A1 is each independently CR2R2'; A2 is each independently CR3CR3'; R2 is each independently a hydrogen atom or the like; R2' is each independently a hydrogen atom or the like; R3 is each independently a hydrogen atom or the like; R3' is each independently a hydrogen atom or the like; m and n are each independently 1 or the like; the ring B is a ring represented by the Formula: wherein: R4 is a group represented by the Formula: wherein: A3 is each independently CR13R13'; A4 is each independently CR14CR14'; R13 is each independently a hydrogen atom or the like; R13' is each independently a hydrogen atom or the like; R14 is each independently a hydrogen atom or the like; R14' is each independently a hydrogen atom |
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