Targeted catalytic complement-activating molecules and methods of use thereof

In one aspect, the present disclosure provides targeted complement-activating molecules comprising a target-binding domain and a complement-activating serine protease effector domain. In some embodiments, the target-binding domain is derived from an antibody or an antigen-binding fragment thereof. A...

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Bibliographische Detailangaben
Hauptverfasser: DEMOPULOS, GREGORY A, DOULAMI, CHRISTIANA, YABUKI, MUNEHISA, SCHWAEBLE, HANS-WILHELM, ALI, MOHAMMED YOUSSIF IBRAHIM
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:In one aspect, the present disclosure provides targeted complement-activating molecules comprising a target-binding domain and a complement-activating serine protease effector domain. In some embodiments, the target-binding domain is derived from an antibody or an antigen-binding fragment thereof. Also provided are compositions and methods for treating cancer, autoimmune disease, or microbial infection, including bacterial, viral, fungal, or parasitic infection, using targeted complement-activating molecules.