Pyrimidine or pyridine derivatives, a preparation method therefor, and a pharmaceutical application thereof

Pyrimidine or pyridine derivatives, a preparation method therefor, and a pharmaceutical application thereof

Disclosed are pyrimidine or pyridine derivatives, a preparation method therefor, and a pharmaceutical application thereof, in particular relating to pyrimidine or pyridine derivatives, having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, a...

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Bibliographische Detailangaben
Hauptverfasser: YU, HONG-PING, FENG, TAO, YANG, SHU-QUN, ZHAO, BAO-WEI, ZHANG, MING-MING, XU, YAOANG, CHEN, ZHUI
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are pyrimidine or pyridine derivatives, a preparation method therefor, and a pharmaceutical application thereof, in particular relating to pyrimidine or pyridine derivatives, having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use of same as an EGFR inhibitor, and a use of same in the preparation of drugs for the treatment and/or prevention of cancers, tumours, or metastatic diseases at least partially related to the insertion, deletion, or other mutation of EGFR exon 20, in particular the use of same in the preparation of drugs for the treatment and/or prevention of hyperproliferative diseases and induced cell death disorders. Each substituent of formula (I) has the same definition as in the description.