Deuterated compound as well as preparation method and application thereof

The invention relates to a deuterated compound and a preparation method and application thereof. The structural formula of the deuterated compound I is shown in the formula (I), A is H or D, and at least one of the eight A is D; m is H or alkali metal, alkaline earth metal or ammonium. The invention...

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Bibliographische Detailangaben
Hauptverfasser:	DUAN, JIAN-XIN, SUN, LIN, LI, BING, JUNG, DONALD T, LI, AN-RONG, CAI, XIAO-HONG, RUAN, MEI-ZHEN, MENG, TENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The invention relates to a deuterated compound and a preparation method and application thereof. The structural formula of the deuterated compound I is shown in the formula (I), A is H or D, and at least one of the eight A is D; m is H or alkali metal, alkaline earth metal or ammonium. The invention provides an application of a deuterated compound I as an interior label in detecting the content of a metabolite II in a biological sample, and the metabolite II has a structural formula shown as a formula (II). Wherein A is H, and M is H or alkali metal, alkaline earth metal or ammonium. The content of the low-content metabolite II in the biological sample is quantitatively analyzed by using the deuterated compound I as an internal standard, the quantitative detection requirement under the low-concentration condition can be met, and the method is suitable for DMPK research in clinical tests.