Use of therapeutic compositions for the treatment of patients with tumors of epithelial origin

The present invention relates to the branches of Biotechnology and Medicine. It describes the use of therapeutic compositions comprising a compound that blocks epidermal growth factor and an antibody that blocks the PD-1/PD-1 ligand signaling pathway in the treatment of tumors of epithelial origin,...

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Bibliographische Detailangaben
Hauptverfasser:	SAAVEDRA HERNANDEZ, DANAY, EVANS, RACHEL, REID, MARY, MESA PARDILLO, CIRCE, LEON MONZON, KALET, MAZORRA HERRERA, ZAIMA, JOHNSON, CANDACE, MUHITCH, JASON, LEE, KELVIN, LORENZO-LUACES ALVAREZ, PATRICIA, DY, GRACE, HUTSON, ALAN, CROMBET RAMOS, TANIA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the branches of Biotechnology and Medicine. It describes the use of therapeutic compositions comprising a compound that blocks epidermal growth factor and an antibody that blocks the PD-1/PD-1 ligand signaling pathway in the treatment of tumors of epithelial origin, particularly those that express the native form for human KRAS protein. In patients with cancer of epithelial origin expressing native KRAS treated with said therapeutic compositions, an increase in their survival was observed.