JAK2 inhibitors and methods of use thereof

JAK2 inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of JAK2 enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TAYLOR, ALEXANDER M, MCLEAN, THOMAS H, FRIDRICH, CARY GRIFFIN, THOMSON, CHRISTOPHER, KURUKULASURIYA, RAVI, SWETT, REBECCA JANE, EVANS, CATHERINE A, BOEZIO, ALESSANDRO, DIPIETRO, LUCIAN V, MADEC, AMAEL
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of JAK2 enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with JAK2 signaling with the compounds and compositions of the disclosure.