Systems, apparatuses, and methods for cellular therapeutics manufacture

Systems, apparatuses, and methods for cellular therapeutics manufacture

Cartridges for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems and instruments for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. T...

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Bibliographische Detailangaben
Hauptverfasser: MASTROIANNI, ALEXANDER J, HUBBARD, JONATHAN CLOUD DRAGON, BEEMILLER, PETER J, LIN, KEIH, MARKS, NATALIE C, LE, LONG VAN, CARDIEL RIVERA, JOSHUA J, KELLY-GREENE, DARCY K, MCFARLAND, ANDREW W, STADLER, GUIDO K
Format: Patent
Sprache:chi ; eng
Schlagworte:
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Cartridges for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems and instruments for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. The population of cells suitable for formulation as a cellular therapeutic can be immunological cells, such as T lymphocytes, including endogenous T cells (ETCs), tumor infiltrating lymphocytes (TILs), CAR T-cells, TCR engineered T-cells, or otherwise engineered T-cells. The systems and methods can be largely automated.