Compositions of programmed death receptor 1 (PD-1) antibodies and methods of obtaining the compositions thereof

Compositions of programmed death receptor 1 (PD-1) antibodies and methods of obtaining the compositions thereof

The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and methods of obtaining the purified compositions. The invention also provides compositions comprising anti-PD...

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Bibliographische Detailangaben
Hauptverfasser: BROWER, MARK A, PINTO, NUNO J. DOS SANTOS, XU, SEN, RICHARDSON, DOUGLAS DENNIS, KWAN, BRIAN WAI, PATEL, BHUMIT A, NAPOLI, WILLIAM NICHOLAS, HUANG, CHUNG-JR
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and methods of obtaining the purified compositions. The invention also provides compositions comprising anti-PD-1 antibody main species and acidic species thereof, wherein the amount of acidic species is about 1.0-12.0%.