Anhydrous polymorphs of androgen receptor antagonist and their preparation and use

The invention belongs to the technical field of pharmaceutical crystal chemistry, and particularly relates to an anhydrous polymorph of an androgen receptor antagonist and a preparation method and application thereof. Specifically, the present invention provides four anhydrous polymorphs of the compound of formula I (with crystal forms A, B, C and D, respectively), methods for preparing each of these anhydrous polymorphs, including these anhydrous polymorphs Pharmaceutical compositions of polymorphs, and uses in the prevention, alleviation and/or treatment of diseases or conditions associated with androgen receptor activity.