Gene-expressing system of non-pathogenic bacteria and transformed strain for metabolizing tyrosine, its use for producing composition of reducing uremic toxins and method of metabolizing tyrosine by using the same

Gene-expressing system of non-pathogenic bacteria and transformed strain for metabolizing tyrosine, its use for producing composition of reducing uremic toxins and method of metabolizing tyrosine by using the same

The invention provides a gene-expressing system of non-pathogenic bacteria for metabolizing tyrosine, in which the gene-expressing system includes a first nucleic acid fragment and a second nucleic acid fragment operably connecting to the first nucleic acid fragment. The aforementioned first nucleic...

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Hauptverfasser: MIRIAM, HUI EMMANUELA, HENG, JI YU, TSAI, CHIA-HUA, HASHIMOTO, MASAYUKI, HSU, TZU-HUAN, HSIEH, CHIEH-EN, NG, I-SON, LAN, YI-JUN, SAMUEL, SABRINA YEO, SUNG, TING-HAN, THAM, FU JIE, CHEN, YENUNG, CHEN, JENN-WEI, HUANG, I-HSIU, YEOH, CHUIN SHUNG, MICHELLE, MEGHIYA, YU, HSINIEH, LIN, MENGIEN
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Zusammenfassung:The invention provides a gene-expressing system of non-pathogenic bacteria for metabolizing tyrosine, in which the gene-expressing system includes a first nucleic acid fragment and a second nucleic acid fragment operably connecting to the first nucleic acid fragment. The aforementioned first nucleic acid fragment and the second nucleic acid fragment have sequences shown in sequence identity number (SEQ ID NO.): 1 and 2, respectively. A transformed strain having the gene-expressing system reduced the amount of tyrosine by converting tyrosine into p-coumaric acid, thereby reducing the amount of uremic toxins.