Recombinant ACE2-FC fusion molecules and methods of making and using thereof

A fusion protein, comprising a variant angiotensin converting enzyme 2 (ACE2) domain covalently fused to a Fc domain. The variant ACE2 domain has a N-terminal deletion, a C-terminal deletion, or both, relative to a full-length wildtype ACE2 having a SEQ ID NO. 1. The variant ACE2 domain has ACE2 act...

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Bibliographische Detailangaben
Hauptverfasser:	KHALILI, JAHAN, ZHANG, YONG, ZHU, YI, LUNDY, STEVEN K, WAIGHT, ANDREW, ZHUO, SHI, TSAI, TSUNG-I, GILCHRIST, MARK, MAK, NGA SZE AMANDA, ZHU, HAI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	A fusion protein, comprising a variant angiotensin converting enzyme 2 (ACE2) domain covalently fused to a Fc domain. The variant ACE2 domain has a N-terminal deletion, a C-terminal deletion, or both, relative to a full-length wildtype ACE2 having a SEQ ID NO. 1. The variant ACE2 domain has ACE2 activity.