Composition for inhibiting ace or suppressing blood pressure elevation, method for producing same, enzyme preparation, polynucleotide and transformant

To provide a composition comprising an ACE inhibitory peptide, a method for producing the same, an enzyme preparation comprising a ligase that is capable of producing the peptide, a polynucleotide having the gene of the ligase, and a transformant. An enzyme preparation comprising a ligase that has t...

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Bibliographische Detailangaben
Hauptverfasser:	OZAKI, TOSHIYA, ROKUDAI, MINORU, NAKANO, YOSHIHISA, ISHIKAWA, TAKAHIRO, KUBO, NOBUKO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a composition comprising an ACE inhibitory peptide, a method for producing the same, an enzyme preparation comprising a ligase that is capable of producing the peptide, a polynucleotide having the gene of the ligase, and a transformant. An enzyme preparation comprising a ligase that has the amino acid sequence represented by SEQ ID NO: 1 or analogous thereto and has the activity of an enzyme selected from among Arg-Asn ligase, Arg-Gln ligase, Asn-Arg ligase and Gln-Arg ligase. A method for producing the composition, said method comprising producing Arg-Asn, Arg-Gln, Asn-Arg and/or Gln-Arg ACE inhibitory dipeptides through an enzymatic reaction with the ligase. A polynucleotide having a base sequence represented by SEQ ID NO: 2 or analogous thereto. A transformant obtained by transforming a microorganism with the polynucleotide. A method for producing the composition, said method comprising culturing the transformant to thereby produce the ACE inhibitory dipeptide.