[1,2,4]triazolo[1,5-C]quinazolin-5-amines

The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and c...

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Hauptverfasser: ROSE, LARS, KOBER, CHRISTINA, MEIER, ROBIN MICHAEL, GUTCHER, ILONA, GORJANACZ, MATYAS, BOTHE, ULRICH, ZORN, LUDWIG, PLATTEN, MICHAEL, LEFRANC, JULIEN, GUNTHER, JUDITH, SCHMEES, NORBERT, STOCKIGT, DETLEF, BAUMANN, DANIEL, BADER, BENJAMIN, BUCHMANN, BERND, BOHME, STEPHAN, HERBERT, SIMON ANTHONY
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.